Predictive factors of ovarian response to GnRH antagonist stimulation protocol: AMH and age are potential candidates

نویسندگان

چکیده

Abstract Background Prediction of ovarian response prior to the stimulation cycle is useful in determining optimal starting dose recombinant follicle-stimulating hormone (r-FSH). This study was designed (I) evaluate which following parameters (age, AMH, and FSH) can be used as a predictor GnRH antagonist protocol, (II) determine cutoff value AMH age for predicting poor high response, (III) investigate relationship between age, level, other clinical parameters. It retrospective study. A total 318 women with mean 28.2 ± 5.9 years old were included this Hormone levels (FSH, LH, PRL, E2, AMH) number collected oocytes determined. Based on retrieved oocytes, participants divided into three groups: (oocytes < 4, n = 51), normal 4–14, 192), > 14, 75). Results significant increase has been found level mature from low group ( P 0.001). Also, significantly greater than groups positive correlation The receiver operating characteristic (ROC) curves showed that both had highest accuracy prediction 1.45 31.5 years, respectively. Additionally, ROC analysis shown accuracy, followed by 3.55 27.5 Conclusions demonstrates women’s may potential predictors protocol.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Predictive factors for ovarian response in a corifollitropin alfa/GnRH antagonist protocol for controlled ovarian stimulation in IVF/ICSI cycles

BACKGROUND This secondary analysis aimed to identify predictors of low (<6 oocytes retrieved) and high ovarian response (>18 oocytes retrieved) in IVF patients undergoing controlled ovarian stimulation with corifollitropin alfa in a gonadotropin-releasing hormone (GnRH) antagonist protocol. METHODS Statistical model building for high and low ovarian response was based on the 150 μg corifollit...

متن کامل

comparison pregnancy outcomes between minimal stimulation protocol and conventional gnrh antagonist protocols in poor ovarian responders

objective: to compare the pregnancy outcomes achieved by in vitro fertilization (ivf) between minimal stimulation and conventional antagonist protocols in poor ovarian responders (pors). materials and methods: in this randomized controlled trial, 77 pors undergoing ivf were selected and divided into two groups. first group was the minimal stimulation group (n = 42) receiving 100 mg/day clomiphe...

متن کامل

What is the value of anti-Müllerian hormone in predicting the response to ovarian stimulation with GnRH agonist and antagonist protocols?

BACKGROUND Anti-Müllerian hormone (AMH) is a marker of the ovarian reserve with promising prognostic potential in reproductive medicine. We aimed to evaluate the prognostic ability of AMH for predicting excessive or poor responses to ovarian stimulation using gonadotrophin-releasing hormone (GnRH) agonist and GnRH antagonist protocols in patients undergoing medically assisted reproduction (MAR)...

متن کامل

Comparison of the standard GnRH antagonist protocol and the luteal phase estradiol/GnRH antagonist priming protocol in poor ovarian responders.

BACKGROUND/AIM The aim of the study was to compare the luteal estradiol patch/GnRH antagonists priming protocol (LPP) with the standard GnRH antagonist protocol in poor ovarian responders (PORs) in terms of the outcomes of in vitro fertilization (IVF) treatment. MATERIALS AND METHODS IVF outcomes of 265 cycles in 265 patients (106 in the LPP group, 159 in the standard GnRH antagonist group) w...

متن کامل

Comparison of GnRH Agonist, GnRH Antagonist, and GnRH Antagonist Mild Protocol of Controlled Ovarian Hyperstimulation in Good Prognosis Patients

The reports on how to stimulate the ovaries for oocyte retrieval in good prognosis patients are contradictory and often favor one type of controlled ovarian hyperstimulation (COH). For this reason, we retrospectively analyzed data from IVF/ICSI cycles carried out at our IVF Unit in good prognosis patients (aged <38 years, first and second attempts of IVF/ICSI, more than 3 oocytes retrieved) to ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Middle East Fertility Society Journal

سال: 2021

ISSN: ['1110-5690', '2090-3251']

DOI: https://doi.org/10.1186/s43043-021-00062-7